collagen cross-linking

patients with keratoconus constitute a large proportion of patients suffering from anterior segment disorders. as of this time, however, its pathogenesis has not yet been elucidated. a reduction in cross-link between collagen molecules has been observed in keratoconic eyes as compared to normal ones. present approaches only address refractive errors resulting from the abnormal abnormal corneal shape. recently, collagen cross-linking using riboflavin and ultraviolet has been introduced to slow down the disease progression. the purpose of the present study is to review the efficacy, clinical outcomes, limitations, and complications of collagen cross-linking.